:root {
  --navy: #082f6b;
  --navy-deep: #061f4b;
  --blue: #087d9f;
  --cyan: #12bbb9;
  --cyan-bright: #18d2cb;
  --ink: #10243e;
  --muted: #5f7084;
  --line: #dce7ee;
  --mist: #eef5f7;
  --white: #ffffff;
  --shadow: 0 24px 70px rgba(8, 47, 107, 0.11);
  --content: 1240px;
  --header-height: 78px;
}

* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
  scroll-padding-top: calc(var(--header-height) + 24px);
}

body {
  margin: 0;
  overflow-x: hidden;
  color: var(--ink);
  background:
    radial-gradient(circle at 8% 4%, rgba(18, 187, 185, 0.12), transparent 22rem),
    #edf3f6;
  font-family: Inter, "Segoe UI", Arial, sans-serif;
  -webkit-font-smoothing: antialiased;
}

a {
  color: inherit;
}

.site-shell {
  width: min(100%, 1500px);
  min-height: 100vh;
  margin: 0 auto;
  background: var(--white);
  box-shadow: var(--shadow);
}

.topbar {
  position: sticky;
  top: 0;
  z-index: 50;
  min-height: var(--header-height);
  border-bottom: 1px solid rgba(8, 47, 107, 0.1);
  background: rgba(255, 255, 255, 0.96);
  backdrop-filter: blur(14px);
}

.topbar__inner {
  width: min(calc(100% - 56px), var(--content));
  min-height: var(--header-height);
  margin: 0 auto;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 32px;
}

.brand {
  flex: 0 0 auto;
  display: inline-flex;
  align-items: center;
}

.brand img {
  display: block;
  width: 152px;
  height: auto;
}

.main-nav {
  display: flex;
  align-items: center;
  justify-content: flex-end;
  gap: clamp(12px, 1.7vw, 28px);
  font-size: 13px;
  font-weight: 650;
  white-space: nowrap;
}

.main-nav a {
  position: relative;
  padding: 12px 0;
  color: #29425f;
  text-decoration: none;
}

.main-nav a:not(.main-nav__contact)::after {
  position: absolute;
  right: 0;
  bottom: 5px;
  left: 0;
  height: 2px;
  content: "";
  background: var(--cyan);
  transform: scaleX(0);
  transform-origin: right;
  transition: transform 180ms ease;
}

.main-nav a:hover::after,
.main-nav a:focus-visible::after,
.main-nav a[aria-current="page"]::after {
  transform: scaleX(1);
  transform-origin: left;
}

.main-nav a[aria-current="page"] {
  color: var(--navy);
}

.main-nav__contact {
  padding: 10px 17px !important;
  color: var(--white) !important;
  border-radius: 999px;
  background: var(--navy);
}

.hero,
.section,
.contact,
footer {
  width: min(calc(100% - 96px), var(--content));
  margin: 0 auto;
}

.hero {
  min-height: 690px;
  display: grid;
  grid-template-columns: minmax(0, 0.96fr) minmax(0, 1.04fr);
  align-items: center;
  gap: clamp(40px, 5vw, 72px);
  padding: 88px 0 96px;
  overflow: hidden;
}

.hero__copy {
  min-width: 0;
}

.eyebrow {
  margin: 0 0 18px;
  color: var(--blue);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: 0.17em;
  text-transform: uppercase;
}

.hero h1,
.section h2,
.contact h2 {
  margin: 0;
  color: var(--navy-deep);
  letter-spacing: -0.045em;
}

.hero h1 {
  max-width: 740px;
  font-size: clamp(44px, 5.2vw, 77px);
  line-height: 1.02;
}

.hero h1 span {
  color: var(--cyan);
}

.hero__intro {
  max-width: 570px;
  margin: 30px 0 0;
  color: var(--muted);
  font-size: clamp(18px, 1.5vw, 22px);
  line-height: 1.55;
}

.hero__actions {
  display: flex;
  flex-wrap: wrap;
  gap: 13px;
  margin-top: 38px;
}

.button {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 48px;
  padding: 0 22px;
  border: 1px solid transparent;
  border-radius: 999px;
  font-size: 14px;
  font-weight: 750;
  text-decoration: none;
  transition: transform 180ms ease, box-shadow 180ms ease, background 180ms ease;
}

.button:hover,
.button:focus-visible {
  transform: translateY(-2px);
}

.button--primary {
  color: var(--white);
  background: linear-gradient(120deg, var(--navy), #0a4c8e);
  box-shadow: 0 12px 28px rgba(8, 47, 107, 0.22);
}

.button--secondary {
  color: var(--navy);
  border-color: #c9d8e4;
  background: var(--white);
}

.hero__visual {
  position: relative;
  min-height: 470px;
  display: flex;
  flex-direction: column;
  justify-content: center;
  gap: 22px;
}

.hero__image-frame {
  position: relative;
  aspect-ratio: 16 / 9;
  overflow: hidden;
  border: 1px solid rgba(8, 47, 107, 0.08);
  border-radius: 28px;
  background: #f9fcfd;
  box-shadow: 0 28px 70px rgba(8, 47, 107, 0.13);
}

.hero__image-frame::after {
  position: absolute;
  inset: 0;
  content: "";
  pointer-events: none;
  box-shadow: inset 0 0 54px rgba(255, 255, 255, 0.58);
}

.hero__image {
  width: 100%;
  height: 100%;
  display: block;
  object-fit: cover;
  object-position: center;
}

.hero__visual-statement {
  max-width: 560px;
  margin: 0 auto;
  color: var(--navy-deep);
  font-size: clamp(20px, 2vw, 28px);
  font-weight: 800;
  line-height: 1.2;
  letter-spacing: -0.025em;
  text-align: center;
}

.hero__visual-statement span {
  color: var(--blue);
}

.section {
  position: relative;
  padding: 112px 0;
  border-top: 1px solid var(--line);
  scroll-margin-top: calc(var(--header-height) + 20px);
}

.section-number {
  margin: 0 0 36px;
  color: #9aabbc;
  font-size: 12px;
  font-weight: 800;
  letter-spacing: 0.15em;
}

.section h2,
.contact h2 {
  max-width: 820px;
  font-size: clamp(36px, 4vw, 58px);
  line-height: 1.08;
}

.section-lead,
.section__preview p,
.contact p {
  color: var(--muted);
  font-size: 18px;
  line-height: 1.65;
}

.section__heading--wide {
  max-width: 900px;
}

.section__intro,
.section--intro {
  display: grid;
  grid-template-columns: 1.1fr 0.9fr;
  gap: clamp(60px, 9vw, 140px);
  align-items: end;
}

.section__preview {
  padding: 32px 0 8px 34px;
  border-left: 3px solid var(--cyan);
}

.section__preview p {
  margin: 0 0 26px;
}

.text-link {
  display: inline-flex;
  gap: 10px;
  align-items: center;
  color: var(--navy);
  font-size: 14px;
  font-weight: 800;
  text-decoration: none;
}

.text-link span {
  color: var(--cyan);
  font-size: 19px;
}

.section--service {
  width: auto;
  max-width: none;
  padding-right: max(48px, calc((100% - var(--content)) / 2));
  padding-left: max(48px, calc((100% - var(--content)) / 2));
  background: linear-gradient(145deg, #f5fafb, #eaf3f6);
}

.service-map {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 18px;
  margin-top: 58px;
}

.service-card {
  min-height: 245px;
  padding: 32px;
  border: 1px solid rgba(8, 47, 107, 0.1);
  border-radius: 22px;
  background: rgba(255, 255, 255, 0.92);
  box-shadow: 0 16px 34px rgba(8, 47, 107, 0.07);
}

.service-card--accent {
  color: var(--white);
  border-color: transparent;
  background: linear-gradient(145deg, var(--navy), #0b4b85);
  transform: translateY(-16px);
}

.service-card__icon {
  display: grid;
  width: 42px;
  height: 42px;
  place-items: center;
  margin-bottom: 44px;
  color: var(--navy);
  border-radius: 50%;
  background: #d8f5f2;
  font-size: 11px;
  font-weight: 850;
}

.service-card h3 {
  margin: 0 0 12px;
  font-size: 25px;
  letter-spacing: -0.025em;
}

.service-card p {
  margin: 0;
  color: var(--muted);
  line-height: 1.55;
}

.service-card--accent p {
  color: rgba(255, 255, 255, 0.76);
}

.more-panel {
  margin-top: 34px;
  border-top: 1px solid rgba(8, 47, 107, 0.16);
}

.more-panel summary,
.faq-list summary {
  padding: 22px 0;
  color: var(--navy);
  cursor: pointer;
  font-weight: 800;
}

.more-panel p,
.faq-list p {
  max-width: 720px;
  margin: 0 0 24px;
  color: var(--muted);
  line-height: 1.6;
}

.section-cta {
  display: inline-flex;
  align-items: center;
  gap: 12px;
  margin-top: 34px;
  color: var(--navy);
  font-size: 15px;
  font-weight: 850;
  text-decoration: none;
}

.section-cta span {
  color: var(--cyan);
  font-size: 20px;
}

/* Interior pages */
.page-hero {
  width: min(calc(100% - 96px), var(--content));
  margin: 0 auto;
  padding: 86px 0 74px;
  border-bottom: 1px solid var(--line);
}

.page-hero--project {
  padding-bottom: 24px;
  border-bottom: 0;
}

.page-hero--project + .content-page {
  padding-top: 34px;
}

.page-hero__kicker {
  display: flex;
  align-items: center;
  gap: 12px;
  margin-bottom: 25px;
  color: var(--blue);
  font-size: 12px;
  font-weight: 850;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}

.page-hero__kicker::before {
  width: 28px;
  height: 2px;
  content: "";
  background: var(--cyan);
}

.page-hero h1 {
  max-width: 970px;
  margin: 0;
  color: var(--navy-deep);
  font-size: clamp(48px, 6vw, 82px);
  line-height: 1.02;
  letter-spacing: -0.052em;
}

.page-hero__lead {
  max-width: 800px;
  margin: 30px 0 0;
  color: var(--muted);
  font-size: clamp(18px, 1.7vw, 23px);
  line-height: 1.6;
}

.page-hero__meta {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  margin-top: 34px;
}

.page-hero__meta span {
  padding: 9px 14px;
  color: var(--navy);
  border: 1px solid #cfe0e7;
  border-radius: 999px;
  background: #f5fafb;
  font-size: 12px;
  font-weight: 750;
}

.module-jump {
  width: min(calc(100% - 96px), var(--content));
  margin: 0 auto;
  padding: 32px 0;
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  border-bottom: 1px solid var(--line);
}

.module-jump a {
  padding: 9px 14px;
  color: #38506a;
  border-radius: 999px;
  background: var(--mist);
  font-size: 12px;
  font-weight: 750;
  text-decoration: none;
}

.module-jump a:hover,
.module-jump a:focus-visible {
  color: var(--white);
  background: var(--navy);
}

.modules {
  width: min(calc(100% - 96px), var(--content));
  margin: 0 auto;
  padding: 0 0 110px;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 22px;
}

.module-card {
  display: grid;
  grid-template-columns: minmax(0, 1fr);
  grid-template-areas:
    "index"
    "title"
    "description"
    "visual"
    "more";
  align-content: start;
  min-width: 0;
  padding: 26px;
  border: 1px solid var(--line);
  border-radius: 22px;
  background: var(--white);
  box-shadow: 0 12px 32px rgba(8, 47, 107, 0.07);
  scroll-margin-top: calc(var(--header-height) + 24px);
  transition: box-shadow 180ms ease, border-color 180ms ease;
}

.module-card:hover {
  border-color: #bfd5df;
  box-shadow: 0 18px 42px rgba(8, 47, 107, 0.11);
}

.module-copy {
  display: contents;
}

.module-art {
  grid-area: visual;
  height: 178px;
  margin: 22px 0 0;
  min-width: 0;
  overflow: hidden;
  border: 1px solid rgba(8, 47, 107, 0.1);
  border-radius: 14px;
  background: #fff;
}

.module-art img {
  display: block;
  width: 100%;
  height: 100%;
  object-fit: contain;
  object-position: center;
}

.module-index {
  grid-area: index;
  margin: 0 0 12px;
  color: var(--cyan);
  font-size: 11px;
  font-weight: 900;
  letter-spacing: 0.16em;
}

.module-copy h2 {
  grid-area: title;
  margin: 0;
  color: var(--navy-deep);
  font-size: clamp(22px, 1.8vw, 28px);
  line-height: 1.14;
  letter-spacing: -0.032em;
}

.module-description {
  grid-area: description;
  margin: 15px 0 0;
  color: var(--muted);
  font-size: 14px;
  line-height: 1.58;
}

.module-more {
  grid-area: more;
  margin-top: 18px;
  border-top: 1px solid var(--line);
}

.module-more summary {
  position: relative;
  padding: 20px 42px 20px 0;
  color: var(--navy);
  cursor: pointer;
  font-size: 14px;
  font-weight: 850;
  list-style: none;
}

.module-more summary::-webkit-details-marker {
  display: none;
}

.module-more summary::after {
  position: absolute;
  top: 50%;
  right: 4px;
  width: 28px;
  height: 28px;
  display: grid;
  place-items: center;
  content: "+";
  color: var(--white);
  border-radius: 50%;
  background: var(--navy);
  transform: translateY(-50%);
}

.module-more[open] summary::after {
  content: "−";
  color: var(--navy);
  background: #d8f5f2;
}

.module-card:has(.module-more[open]) {
  grid-column: 1 / -1;
  grid-template-columns: minmax(260px, 0.82fr) minmax(0, 1.18fr);
  grid-template-areas:
    "index visual"
    "title visual"
    "description visual"
    "more more";
  column-gap: clamp(36px, 6vw, 86px);
  padding: clamp(30px, 4vw, 54px);
  border-color: #bcd6df;
  background: linear-gradient(145deg, #ffffff, #f3f9fa);
  box-shadow: 0 24px 60px rgba(8, 47, 107, 0.13);
}

.module-card:has(.module-more[open]) .module-art {
  height: 390px;
  margin: 0;
  border-radius: 20px;
  box-shadow: 0 18px 40px rgba(8, 47, 107, 0.1);
}

.module-card:has(.module-more[open]) .module-copy h2 {
  font-size: clamp(32px, 3vw, 45px);
}

.module-card:has(.module-more[open]) .module-description {
  font-size: 17px;
}

.module-qa {
  margin: 0;
  padding: 8px 0 4px;
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  column-gap: clamp(30px, 5vw, 70px);
}

.module-qa div {
  padding: 17px 0;
  border-top: 1px solid #e8eef2;
}

.module-qa dt {
  color: var(--navy);
  font-size: 14px;
  font-weight: 850;
  line-height: 1.45;
}

.module-qa dd {
  margin: 7px 0 0;
  color: var(--muted);
  font-size: 14px;
  line-height: 1.62;
}

.module-note {
  width: min(calc(100% - 96px), var(--content));
  margin: 38px auto 34px;
  padding: 20px 26px;
  color: #456078;
  border-left: 4px solid var(--cyan);
  background: #f2f8f9;
  font-size: 14px;
  line-height: 1.6;
}

.content-page {
  width: min(calc(100% - 96px), var(--content));
  min-height: 460px;
  margin: 0 auto;
  padding: 80px 0 110px;
}

.placeholder-band {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 18px;
  margin-top: 48px;
}

.placeholder-band article {
  min-height: 190px;
  padding: 28px;
  border: 1px solid var(--line);
  border-radius: 20px;
  background: linear-gradient(145deg, var(--white), #f2f8f9);
}

.placeholder-band h2 {
  margin: 0 0 12px;
  color: var(--navy);
  font-size: 21px;
}

.placeholder-band p {
  color: var(--muted);
  line-height: 1.6;
}

.contact-direct {
  margin-top: 22px;
  padding: 30px 32px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 32px;
  border-radius: 20px;
  color: var(--white);
  background: linear-gradient(120deg, var(--navy-deep), var(--navy));
}

.contact-direct p {
  margin: 0;
  color: rgba(255, 255, 255, 0.78);
  line-height: 1.55;
}

.contact-direct .contact-direct__label {
  margin-bottom: 6px;
  color: var(--cyan-bright);
  font-size: 11px;
  font-weight: 800;
  letter-spacing: .15em;
  text-transform: uppercase;
}

.contact-direct > a {
  flex: 0 0 auto;
  color: var(--white);
  font-size: clamp(19px, 2.1vw, 28px);
  font-weight: 800;
  letter-spacing: -.02em;
  text-decoration: none;
}

.contact-direct > a span {
  color: var(--cyan-bright);
}

.team-page {
  padding-top: 72px;
}

.lead-profile {
  display: grid;
  grid-template-columns: minmax(300px, 0.78fr) minmax(0, 1.22fr);
  gap: clamp(48px, 7vw, 104px);
  align-items: center;
  padding-bottom: 92px;
  border-bottom: 1px solid var(--line);
}

.lead-profile__portrait {
  position: relative;
  margin: 0;
}

.lead-profile__portrait::before {
  position: absolute;
  inset: 24px -20px -20px 24px;
  z-index: -1;
  content: "";
  border-radius: 28px;
  background: linear-gradient(145deg, rgba(18, 187, 185, 0.22), rgba(8, 47, 107, 0.14));
}

.lead-profile__portrait img {
  display: block;
  width: 100%;
  aspect-ratio: 4 / 5;
  object-fit: cover;
  border-radius: 28px;
  box-shadow: 0 24px 60px rgba(8, 47, 107, 0.16);
}

.profile-label,
.collaborator-type {
  margin: 0 0 16px;
  color: var(--cyan-deep);
  font-size: 12px;
  font-weight: 850;
  letter-spacing: 0.14em;
  text-transform: uppercase;
}

.lead-profile__content h2,
.collaborators__header h2 {
  margin: 0;
  color: var(--navy-deep);
  font-size: clamp(36px, 4.5vw, 60px);
  line-height: 1.05;
  letter-spacing: -0.035em;
}

.profile-role {
  margin: 12px 0 28px;
  color: var(--blue);
  font-size: 18px;
  font-weight: 800;
}

.lead-profile__content > p:not(.profile-label):not(.profile-role),
.scientific-advisor > p:not(.collaborator-type):not(.profile-role),
.collaboration-network > p:not(.collaborator-type) {
  margin: 0 0 18px;
  color: var(--muted);
  font-size: 16px;
  line-height: 1.72;
}

.profile-expertise {
  display: flex;
  flex-wrap: wrap;
  gap: 9px;
  margin: 30px 0 0;
  padding: 0;
  list-style: none;
}

.profile-contact {
  margin-top: 28px;
  padding-top: 22px;
  display: flex;
  flex-wrap: wrap;
  align-items: baseline;
  gap: 8px 18px;
  border-top: 1px solid var(--line);
}

.profile-contact span {
  color: #8798aa;
  font-size: 11px;
  font-weight: 800;
  letter-spacing: .14em;
  text-transform: uppercase;
}

.profile-contact a {
  color: var(--blue);
  font-size: 17px;
  font-weight: 800;
  text-decoration-thickness: 1px;
  text-underline-offset: 4px;
}

.contact__email {
  display: inline-block;
  margin-top: 16px;
  color: var(--cyan-bright);
  font-size: 17px;
  font-weight: 800;
  text-decoration-thickness: 1px;
  text-underline-offset: 4px;
}

.profile-expertise li {
  padding: 9px 13px;
  color: var(--navy);
  border: 1px solid #cfe0e7;
  border-radius: 999px;
  background: #f5fafb;
  font-size: 12px;
  font-weight: 750;
}

.collaborators {
  padding-top: 88px;
}

.collaborators__header {
  max-width: 760px;
  margin-bottom: 52px;
}

.collaborators__header > p:last-child {
  margin: 22px 0 0;
  color: var(--muted);
  font-size: 18px;
  line-height: 1.6;
}

.collaborator-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 24px;
}

.scientific-advisor,
.collaboration-network {
  min-height: 400px;
  padding: clamp(32px, 4vw, 54px);
  border-radius: 28px;
}

.scientific-advisor {
  border: 1px solid var(--line);
  background: linear-gradient(145deg, var(--white), #f3f8fa);
}

.collaboration-network {
  background: linear-gradient(145deg, var(--navy-deep), var(--blue));
}

.scientific-advisor h3,
.collaboration-network h3 {
  margin: 0;
  font-size: clamp(25px, 3vw, 36px);
  line-height: 1.12;
  letter-spacing: -0.025em;
}

.scientific-advisor h3 {
  color: var(--navy-deep);
}

.collaboration-network h3 {
  margin-bottom: 28px;
  color: var(--white);
}

.collaboration-network .collaborator-type {
  color: #6fe7e3;
}

.collaboration-network > p:not(.collaborator-type) {
  color: rgba(255, 255, 255, 0.82);
}

.science-page {
  padding-top: 72px;
}

.evidence-intro {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 230px;
  gap: clamp(48px, 8vw, 120px);
  align-items: end;
  padding-bottom: 76px;
}

.evidence-intro h2 {
  max-width: 780px;
  margin: 0;
  color: var(--navy-deep);
  font-size: clamp(36px, 4.5vw, 60px);
  line-height: 1.05;
  letter-spacing: -0.035em;
}

.evidence-intro > div:first-child > p:last-child {
  max-width: 760px;
  margin: 24px 0 0;
  color: var(--muted);
  font-size: 18px;
  line-height: 1.65;
}

.evidence-stat {
  padding: 28px 0 8px 30px;
  border-left: 3px solid var(--cyan);
}

.evidence-stat strong,
.evidence-stat span {
  display: block;
}

.evidence-stat strong {
  color: var(--navy-deep);
  font-size: clamp(58px, 7vw, 86px);
  line-height: 0.9;
  letter-spacing: -0.06em;
}

.evidence-stat span {
  margin-top: 15px;
  color: var(--muted);
  font-size: 13px;
  font-weight: 800;
  letter-spacing: 0.08em;
  text-transform: uppercase;
}

.therapeutic-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 24px;
}

.therapeutic-card {
  align-self: start;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 26px;
  background: var(--white);
  box-shadow: 0 16px 42px rgba(8, 47, 107, 0.07);
}

.therapeutic-card > header {
  min-height: 250px;
  padding: 34px 36px 30px;
  background: linear-gradient(145deg, #ffffff, #f4f9fa);
}

.therapeutic-card > header > span {
  display: block;
  margin-bottom: 38px;
  color: var(--cyan-deep);
  font-size: 11px;
  font-weight: 850;
  letter-spacing: 0.12em;
}

.therapeutic-card h3 {
  margin: 0;
  color: var(--navy-deep);
  font-size: clamp(24px, 2.7vw, 34px);
  line-height: 1.1;
  letter-spacing: -0.025em;
}

.therapeutic-card > header p {
  margin: 18px 0 0;
  color: var(--muted);
  font-size: 15px;
  line-height: 1.65;
}

.therapeutic-card--methods {
  grid-column: 1 / -1;
}

.therapeutic-card--methods > header {
  min-height: 0;
}

.evidence-details {
  border-top: 1px solid var(--line);
}

.evidence-details summary {
  position: relative;
  padding: 22px 70px 22px 36px;
  color: var(--blue);
  font-size: 14px;
  font-weight: 850;
  cursor: pointer;
  list-style: none;
}

.evidence-details summary::-webkit-details-marker {
  display: none;
}

.evidence-details summary::after {
  position: absolute;
  top: 50%;
  right: 34px;
  content: "+";
  color: var(--cyan-deep);
  font-size: 24px;
  font-weight: 500;
  transform: translateY(-52%);
}

.evidence-details[open] summary::after {
  content: "−";
}

.evidence-details[open] summary {
  background: #f6fafb;
}

.evidence-content {
  padding: 8px 36px 38px;
  border-top: 1px solid #e9f0f3;
}

.evidence-heading {
  margin: 30px 0 14px;
  color: var(--navy);
  font-size: 11px;
  font-weight: 900;
  letter-spacing: 0.13em;
  text-transform: uppercase;
}

.publication-list,
.project-list {
  margin: 0;
  padding: 0;
  list-style: none;
}

.publication-list li,
.project-list li {
  padding: 15px 0;
  border-top: 1px solid #e8eef2;
}

.publication-list a,
.publication-title,
.project-list a {
  display: block;
  color: var(--navy-deep);
  font-size: 14px;
  font-weight: 750;
  line-height: 1.45;
}

.publication-list a,
.project-list a {
  text-decoration-color: rgba(18, 187, 185, 0.45);
  text-decoration-thickness: 1px;
  text-underline-offset: 3px;
}

.publication-list a:hover,
.project-list a:hover {
  color: var(--blue);
}

.publication-list small,
.project-list small {
  display: block;
  margin-top: 6px;
  color: #718296;
  font-size: 12px;
  line-height: 1.45;
}

.scope-band {
  margin-top: 76px;
  padding: clamp(42px, 6vw, 76px);
  border-radius: 30px;
  background: linear-gradient(145deg, var(--navy-deep), var(--blue));
}

.scope-band .profile-label {
  color: #6fe7e3;
}

.scope-band h2 {
  max-width: 900px;
  margin: 0;
  color: var(--white);
  font-size: clamp(34px, 4.5vw, 58px);
  line-height: 1.07;
  letter-spacing: -0.035em;
}

.scope-band > p:last-child {
  max-width: 880px;
  margin: 28px 0 0;
  color: rgba(255, 255, 255, 0.82);
  font-size: 17px;
  line-height: 1.7;
}

.process {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 0;
  margin: 70px 0 0;
  padding: 0;
  list-style: none;
}

.process li {
  position: relative;
  min-height: 190px;
  padding: 28px 25px;
  border-top: 2px solid var(--line);
}

.process li::before {
  position: absolute;
  top: -7px;
  left: 28px;
  width: 12px;
  height: 12px;
  content: "";
  border-radius: 50%;
  background: var(--cyan);
  box-shadow: 0 0 0 7px rgba(18, 187, 185, 0.15);
}

.process span,
.process strong,
.process small {
  display: block;
}

.process span {
  margin-bottom: 36px;
  color: #92a5b7;
  font-size: 11px;
  font-weight: 800;
}

.process strong {
  margin-bottom: 9px;
  color: var(--navy);
  font-size: 20px;
}

.process small {
  color: var(--muted);
  font-size: 14px;
  line-height: 1.45;
}

.section--science {
  display: grid;
  grid-template-columns: 0.8fr 1.2fr;
  gap: clamp(60px, 9vw, 140px);
  align-items: center;
}

.science-visual {
  position: relative;
  min-height: 390px;
  overflow: hidden;
  border-radius: 28px;
  background:
    linear-gradient(rgba(255, 255, 255, 0.08) 1px, transparent 1px),
    linear-gradient(90deg, rgba(255, 255, 255, 0.08) 1px, transparent 1px),
    linear-gradient(145deg, var(--navy-deep), var(--navy));
  background-size: 32px 32px, 32px 32px, auto;
  box-shadow: 0 25px 55px rgba(8, 47, 107, 0.18);
}

.science-visual__core {
  position: absolute;
  top: 50%;
  left: 50%;
  width: 76px;
  height: 76px;
  border: 16px solid rgba(255, 255, 255, 0.72);
  border-radius: 50%;
  background: var(--cyan-bright);
  box-shadow: 0 0 50px var(--cyan);
  transform: translate(-50%, -50%);
}

.data-line {
  position: absolute;
  height: 2px;
  background: linear-gradient(90deg, transparent, var(--cyan), transparent);
  transform-origin: center;
}

.data-line--one {
  top: 34%;
  left: 8%;
  width: 84%;
  transform: rotate(18deg);
}

.data-line--two {
  top: 62%;
  left: 4%;
  width: 92%;
  transform: rotate(-22deg);
}

.data-line--three {
  top: 50%;
  left: 12%;
  width: 76%;
  transform: rotate(90deg);
}

.section--science .text-link {
  margin-top: 20px;
}

.section--faq {
  display: grid;
  grid-template-columns: 0.8fr 1.2fr;
  gap: clamp(60px, 9vw, 140px);
  align-items: start;
}

.faq-list {
  max-width: 1040px;
  margin: 0 auto;
  border-top: 1px solid var(--line);
}

.faq-list details {
  border-bottom: 1px solid var(--line);
}

.faq-list summary {
  position: relative;
  padding: 27px 190px 27px 6px;
  font-size: 17px;
  line-height: 1.45;
  list-style: none;
}

.faq-list summary::-webkit-details-marker {
  display: none;
}

.faq-list summary::after {
  content: "Show answer  +";
  position: absolute;
  top: 50%;
  right: 6px;
  color: var(--teal-dark);
  font-size: 12px;
  font-weight: 800;
  letter-spacing: .05em;
  text-transform: uppercase;
  transform: translateY(-50%);
}

.faq-list details[open] summary::after {
  content: "Hide answer  −";
}

.faq-list details[open] summary {
  padding-bottom: 18px;
}

.faq-answer {
  max-width: 900px;
  padding: 0 6px 28px;
}

.faq-answer p {
  max-width: none;
  margin: 0;
  padding: 0;
}

.faq-answer p + p {
  margin-top: 13px;
}

.faq-answer a {
  color: var(--teal-dark);
  font-weight: 750;
  text-decoration-thickness: 1px;
  text-underline-offset: 3px;
}

.faq-answer a:hover {
  color: var(--navy);
}

.contact {
  min-height: 360px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 60px;
  margin-bottom: 52px;
  padding: 60px clamp(34px, 6vw, 84px);
  color: var(--white);
  border-radius: 30px;
  background:
    radial-gradient(circle at 88% 18%, rgba(24, 210, 203, 0.33), transparent 15rem),
    linear-gradient(135deg, var(--navy-deep), var(--navy));
  box-shadow: 0 28px 65px rgba(8, 47, 107, 0.2);
  scroll-margin-top: calc(var(--header-height) + 28px);
}

.contact h2 {
  max-width: 720px;
  color: var(--white);
}

.contact p {
  max-width: 690px;
  margin-bottom: 0;
  color: rgba(255, 255, 255, 0.72);
}

.eyebrow--light {
  color: var(--cyan-bright);
}

.button--light {
  flex: 0 0 auto;
  gap: 10px;
  color: var(--navy);
  background: var(--white);
}

footer {
  min-height: 130px;
  display: grid;
  grid-template-columns: 180px 1fr auto;
  align-items: center;
  gap: 40px;
  border-top: 1px solid var(--line);
  color: #718296;
  font-size: 12px;
}

footer img {
  width: 145px;
}

footer p:last-child {
  text-align: right;
}

footer a {
  color: inherit;
  text-underline-offset: 3px;
}

summary::marker {
  color: var(--cyan);
}

:focus-visible {
  outline: 3px solid rgba(18, 187, 185, 0.55);
  outline-offset: 4px;
}

@media (max-width: 1100px) {
  :root {
    --header-height: 112px;
  }

  .topbar__inner {
    width: min(calc(100% - 40px), var(--content));
    padding-top: 12px;
    display: block;
  }

  .brand img {
    width: 128px;
  }

  .main-nav {
    justify-content: flex-start;
    gap: 23px;
    margin-top: 7px;
    padding-bottom: 10px;
    overflow-x: auto;
    scrollbar-width: none;
  }

  .main-nav::-webkit-scrollbar {
    display: none;
  }

  .main-nav__contact {
    padding: 7px 13px !important;
  }
}

@media (max-width: 820px) {
  .hero,
  .section,
  .contact,
  footer,
  .page-hero,
  .module-jump,
  .modules,
  .module-note,
  .content-page {
    width: min(calc(100% - 40px), var(--content));
  }

  .hero {
    min-height: auto;
    grid-template-columns: 1fr;
    padding: 72px 0 62px;
  }

  .hero__visual {
    min-height: 0;
    margin-top: 10px;
  }

  .section {
    padding: 82px 0;
  }

  .section--intro,
  .section--science,
  .section--faq {
    grid-template-columns: 1fr;
    gap: 52px;
  }

  .page-hero {
    padding: 68px 0 58px;
  }

  .page-hero--project {
    padding-bottom: 24px;
  }

  .modules {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .module-card {
    grid-template-columns: 1fr;
    gap: 0;
    padding: 24px;
  }

  .module-card:has(.module-more[open]) {
    grid-template-columns: 1fr;
    grid-template-areas:
      "index"
      "title"
      "description"
      "visual"
      "more";
  }

  .module-card:has(.module-more[open]) .module-art {
    height: 360px;
    margin-top: 26px;
  }

  .module-qa {
    grid-template-columns: 1fr;
  }

  .placeholder-band {
    grid-template-columns: 1fr;
  }

  .contact-direct {
    align-items: flex-start;
    flex-direction: column;
  }

  .lead-profile,
  .collaborator-grid,
  .evidence-intro,
  .therapeutic-grid {
    grid-template-columns: 1fr;
  }

  .evidence-stat {
    width: min(100%, 280px);
  }

  .therapeutic-card--methods {
    grid-column: auto;
  }

  .lead-profile__portrait {
    width: min(100%, 520px);
  }

  .scientific-advisor,
  .collaboration-network {
    min-height: 0;
  }

  .section--service {
    width: auto;
    padding-right: 20px;
    padding-left: 20px;
  }

  .service-map {
    grid-template-columns: 1fr;
  }

  .service-card,
  .service-card--accent {
    min-height: 210px;
    transform: none;
  }

  .process {
    grid-template-columns: 1fr 1fr;
  }

  .contact {
    min-height: 420px;
    align-items: flex-start;
    flex-direction: column;
    justify-content: center;
    padding: 45px 32px;
  }

  footer {
    grid-template-columns: 1fr;
    gap: 8px;
    padding: 38px 0;
  }

  footer p {
    margin: 0;
  }

  footer p:last-child {
    text-align: left;
  }
}

@media (max-width: 520px) {
  :root {
    --header-height: 108px;
  }

  .topbar__inner {
    width: calc(100% - 28px);
  }

  .main-nav {
    gap: 18px;
    font-size: 12px;
  }

  .hero,
  .section,
  .contact,
  footer,
  .page-hero,
  .module-jump,
  .modules,
  .module-note,
  .content-page {
    width: calc(100% - 32px);
  }

  .page-hero h1 {
    font-size: 43px;
  }

  .module-jump {
    flex-wrap: nowrap;
    overflow-x: auto;
    scrollbar-width: none;
  }

  .modules {
    grid-template-columns: 1fr;
  }

  .module-card:has(.module-more[open]) .module-art {
    height: 285px;
  }

  .module-jump::-webkit-scrollbar {
    display: none;
  }

  .module-art {
    border-radius: 20px;
  }

  .hero h1 {
    max-width: 100%;
    font-size: 38px;
    overflow-wrap: break-word;
  }

  .hero__actions {
    display: grid;
  }

  .hero__visual {
    min-height: 0;
  }

  .hero__image-frame {
    border-radius: 20px;
  }

  .hero__visual-statement {
    font-size: 20px;
  }

  .section h2,
  .contact h2 {
    font-size: 36px;
  }

  .section__preview {
    padding-left: 22px;
  }

  .service-card {
    padding: 27px;
  }

  .process {
    grid-template-columns: 1fr;
  }

  .process li {
    min-height: 150px;
  }

  .team-page {
    padding-top: 50px;
  }

  .science-page {
    padding-top: 50px;
  }

  .lead-profile {
    gap: 48px;
    padding-bottom: 64px;
  }

  .collaborators {
    padding-top: 64px;
  }

  .collaborators__header {
    margin-bottom: 36px;
  }

  .evidence-intro {
    gap: 40px;
    padding-bottom: 54px;
  }

  .therapeutic-card > header {
    min-height: 0;
    padding: 28px 26px 26px;
  }

  .therapeutic-card > header > span {
    margin-bottom: 28px;
  }

  .evidence-details summary {
    padding-right: 58px;
    padding-left: 26px;
  }

  .evidence-details summary::after {
    right: 24px;
  }

  .evidence-content {
    padding-right: 26px;
    padding-left: 26px;
  }

  .science-visual {
    min-height: 310px;
  }

  .faq-list summary {
    padding-right: 48px;
  }

  .faq-list summary::after {
    content: "+";
    font-size: 18px;
    letter-spacing: 0;
  }

  .faq-list details[open] summary::after {
    content: "−";
  }

  .contact {
    margin-bottom: 24px;
    border-radius: 22px;
  }
}

@media (prefers-reduced-motion: reduce) {
  html {
    scroll-behavior: auto;
  }

  *,
  *::before,
  *::after {
    transition-duration: 0.01ms !important;
  }
}